Four G protein gated inwardly-rectifying potassium (GIRK) channel subunits have been identified in mammals: GIRK1, GIRK2, GIRK3, and GIRK4. The GIRK subunits come together to form GIRK ion channels.
G protein-gated inwardly rectifying potassium (GIRK) channels hyperpolarize neurons in respogirknse to activation of many different G protein-coupled receptors and thus control the excitability of neurons through GIRK-mediated self-inhibition, slow synaptic potentials and volume transmission.
G Protein-Coupled Ingirkwardly-Rectifying Potassium Channels (GIRK channels) are channels found in the brain that play a crucial role in the inhibitory effects of neurotransmitters.
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